Vinyl Chloride And Hcc

The results from the two large multicenter studies and the pooled meta analysis are presented in table 2.

Vinyl chloride and hcc.

Vinyl chloride and hcc the most up to date and most comprehensive analyses is a pooled analyses of cohorts of vcm workers from plants in the usa and europe 41. The results from the. Recently the international agency for research on cancer has also included vc among the definite causes of hcc 1 but this assumption is not. In vc associated las mutations of the k ras 2 gene have been reported.

Vinyl chloride is extensively used in the plastic industry and it is a well recognized risk factor for development of asl which is an extremely rare neoplasia when not associated with vc exposure. Objective to evaluate mortality risks of angiosarcoma of the liver asl primary hepatocellular carcinoma hcc and other cancers among 9951 men employed between 1942 and 1972 at 35 us vinyl chloride vc or polyvinyl chloride plants followed for mortality through 31 december 2013. About 13 billion kilograms are produced annually. Vinyl chloride is a chlorinated hydrocarbon occurring as a colorless highly flammable gas with a mild sweet odor that may emit toxic fumes of carbon dioxide carbon monoxide hydrogen chloride and phosgene when heated to decomposition.

Vinyl chloride is primarily used to make polyvinyl chloride to manufacture plastics. In 2007 the international agency for research on cancer established the association of vcm with hepatocellular carcinoma hcc though only on the basis of the few cases available. In fact the assessment of vinyl chloride as a cause of hcc is complicated because most studies do not have histological or other definitive clinical information to discriminate hcc from asl and or secondary neoplasms. In 2007 the international agency for research on cancer established the association of vcm with hepatocellular carcinoma hcc though o.

Vinyl chloride is an organochloride with the formula h 2 c chcl that is also called vinyl chloride monomer vcm or chloroethene this colorless compound is an important industrial chemical chiefly used to produce the polymer polyvinyl chloride pvc. Portal hypertension liver fibrosis and angiosarcoma of the liver asl have been reported among workers exposed to vinyl chloride monomer vcm since the 1970s. 2 after the first report of three cases of asl in subjects employed in the manufacture of pvc resins 15 epidemiological. Vinyl chloride and hcc.

Plants in the usa and europe 41. Portal hypertension liver fibrosis and angiosarcoma of the liver asl have been reported among workers exposed to vinyl chloride monomer vcm since the 1970s. Methods smr and time dependent cox proportional hazards analyses were used to evaluate mortality risks by.